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Renal Transplant Center

What we do

[Kidney function and renal failure at the end stage]
Kidneys are organs on the back slightly above the waist, one on each side (usually two per person). The main function of the kidneys is to remove waste products in the body by filtering the blood to make urine and excreting it, and to keep and adjust the amount and composition of body fluid (electrolytes such as sodium and potassium and the balance of acidity and alkalinity). In addition, it also plays a role in the secretion of hormones that maintain blood pressure and hormones that make blood, and the activation of vitamin D that maintains bones.

[About dialysis]
There are two types of dialysis, "hemodialysis" and "peritoneal dialysis". Although the treatment with dialysis has advanced in recent years, it is not a fundamental treatment because it is a symptomatic treatment that merely substitutes one-tenth the function of a normal kidney.

[About renal transplantation]
Kidney transplantation is a treatment method to restore the function of the lost kidney by transplanting the kidney donated to the end-stage renal failure (recipient), and is the only radical treatment method for end-stage renal failure. You will be released from dialysis, and you will be able to reduce the quality of life (QOL) and complications that dialysis suffers, and you will be able to live a life similar to healthy people.

[Conditions for living kidney transplantation]
In order to receive treatment by living-donor transplantation, certain conditions are required for both the donor (donor) and the recipient (recipient) of the kidney.

[Examination before living kidney transplantation]
Before performing a living kidney transplant, first, blood is collected in an outpatient department, and a donor-recipient histocompatibility test (organ compatibility) and an infectious disease test are performed. As a result of histocompatibility test, strong rejection may be expected and transplantation may be determined to be difficult. In addition, the recipient will not be able to receive some vaccination after starting the immunosuppressive drug, so the recipient will receive the necessary vaccine before surgery.

[Biological kidney transplantation]
Recipients are basically hospitalized one week before transplant surgery and begin using immunosuppressants. If there is an antibody (anti-donor antibody) to the donor that is revealed by blood group mismatch transplantation or histocompatibility test, plasmapheresis to remove the antibody is also performed. Donors are hospitalized the day before transplantation.

[Life after transplantation]
After transplantation, not only the recipient but also the donor needs to visit the clinic regularly.
Recipients will be examined at the outpatient department of renal transplantation, including kidney function, to check whether side effects of immunosuppressive drugs, infections, or malignant diseases have occurred. As a guideline for the interval between visits, it is necessary to visit the doctor once or twice a week for up to 3 months after the transplantation, once every 2 weeks for the next 3 months and once a month for 6 months or more.

[Results of renal transplantation (quoted from the Japan Society for Transplantation 2016 organ transplant factbook)]
In the year 2015, 1,661 renal transplants were performed in Japan, of which 1,494 were living kidney transplantation and 167 were donated kidney transplants. The engraftment rate of transplanted kidneys has improved with the progress of immunosuppressants. Regarding the 1-year engraftment rate and the 5-year engraftment rate in recent years (2010-2014), 98.7%, 94.6%, and The port rates are 96.4% and 87.5%.
  1. What we do